脳外科疾患に対するCDP-Choline （Ensign）の臨床治験

CLINICAL EXPERIMENTS WITH CDP-CHOLINE FOR THE TRETMENT OF NEURO-SURGICAL DISTURBANCES

緒言

　脳代謝賦活作用があり，特に意識障害の改善にすぐれた効果を示すといわれるCDP-Cholimeを臨床例に使用して得た結果をここに報告する。臨床症状特に意識障害，精神症状，脳波所見などに着目してその効果について検索してみた。

To a total of 37 patients suffering from cerebral injury, cerebral tumor, traumatic cervical syndromes, spinal injury and etc, was infused CDP-Choline (Ensign) by dissolving it into 500 ml. for a dura-tions of 5-98 days, with a daily dose of 500 mgs. in principle. In cases out of them, it was admini-stered directly to artery via carotid puncture, acco-rding to the conditions of the patients.

An overall evalution was made of the clinical effect iveness of the medication from the viewpo-int of findings connected to clouding of consciou-sness, psychotic symptoms, neurotic symptoms, su-bjective symptoms, eletro-encepharograph and X-ray examinations.

It resulted the drug was significantly effective in 7 cases, effective in 19, slightly effective in 5 and not effective in 7, out of 37 cases in all, signifyi-ng its effective rate of 84%.

The drug exhibited a remarkable efficiency for the tretment of clouding of consciousness and psyc-hotic symptoms, and it may be expected to bring about the desired effect to relieve feeling of num-bness or weakness and alleviate pain associated to the patients. There was not a single side effect en-countered.