雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

ON THE ANTIEPILEPTIC ACTIVITIES OF A NEW COMPOUND ETHOXYCARBODIPHENYLHYDANTOIN Shuji TAEN 1 , Yoko GOTO 1 , Kazue SEKIBA 1 , Susumu ARAI 1 1Dept. of Neuropsychiatry, Univ. of Tokyo, School of Medicine pp.977-981
Published Date 1964/11/1
DOI https://doi.org/10.11477/mf.1406201738
  • Abstract
  • Look Inside

We have previously reported that the introduction of ethoxycarboradical into the chemical structure of straight-chain compounds may improve their a nti-epileptic activities.

As the next step, we have tried to scrutinize the antiepileptic activities of a new compound Ethoxy-carbosubstituted derivative on 3-N position of 5,5- diphenylhydantoin which to date is accepted as one of the most potent anticonvulsants among hydantoins.

After confirming the lower toxicity and higher potencies in preventing electro- and metrazol-con-vulsions in comparison with 5,5-diphenylhydantoin on animals, we have administered this new com-pound upon 42 epileptics consisting mainly of chronic refractory cases with various seizure types.

Ethoxycarbodiphenylhydantoin has proved the most effective in grand mal type of seizures and controlled the seizures in 46,9% completely. It was also effec-tive in myoclonic and psychomotor seizures. As a whole its spectrum as an antiepileptic seemed rather similar to that of 5,5-diphenylhydantoin. Side-effects were also similar to those of 5,5-diphenylhydantoin, ataxia being the most frequent. Gum-hypertrophy has not been noticed so far. There have been often observed individual differences among the patients to these two drugs both in effects and side-effects and the determination of relative merits requires further studies.

However, the data compiled seems to show that this new compound is an effective anticonvulsant and to warrant clinical application.


Copyright © 1964, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

関連文献

もっと見る

文献を共有