抗抑うつ剤および電気衝撃の自律神経系におよぼす影響

EFFECT OF ANTIDEPRESSANTS AND ELECTRIC CONVULSIVE SHOCK ON AUTONOMIC NERVOUS SYSTEM

I．はじめに

　近来，精神科領域に薬物療法が登場して以来，抑うつ状態の治療にも今までの電撃療法のみならず多数の薬剤が導入されかなりの成果をあげている。

　一方，精神病の心理状態の改善と交感神経系の反応の変化が平行することが注目され，電撃療法の治療効果も交感神経系の刺激にあるとする説^{1）8）9）12）}が提唱された。さらに，うつ状態では自律神経機能の面で，血圧・体温・基礎代謝の低下脈搏減少を示して交感神経抑制に傾むき，うつ病群では一般に交感神経系の反応性が低いといわれている^29）。

The effects of antidepressants (Imipramine, Amitriptyline and JB-516) and electric con-vulsive shock were studied on the vasopres-sor responses of Noradrenaline, Adrenaline and Tyramine in anesthetized dogs. Imipra-mine, Amitriptyline and JB-516 were injected intravenously. As electric convulsive shock 100V. A. C. stimulus was administered for 3-5 seconds by frontal leads.

1. Imipramine and Amitriptyline showed two phasic actions, adrenolytic (sedative) and adrenopotentiating (antidepressive) and Amitriptyline was more potent than Imipra-mine in adrenolytic action. But they preven-ted the vasopressor responses of Tyramine. This potent adrenolytic action of Amitripty-line is supposed to have sedative effects on patient's anxiety.

2. JB-516 (potent Monoamineoxidase In-hibitor) increased the vasopressor responses of Noradrenaline, Adrenaline and Tyramine, espe:ially that of Tyramine.

3. Electric convulsive shock also showed the remarkable vasopressor responses of these three amines for hours from about 30 minutes after administration.

4. Imipramine, Amitriptyline and JB-516 have no own sympathomimetic actions unlike some central nervous stimulants such as Amphetamine, Pipradol etc. and are assumed to potentiate the action of Noradrenaline which is liberated physiologically, showing antidepressant actions.