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緒言
鬱病や鬱状態にある精神疾患の治療には,従来,電撃療法や持続睡眠療法がおこなわれている。ことに電撃療法は,もつとも効果のある療法で,このことは昨年度の成医会総会における野村の特別講演の中でも資料をあげて報告されているが,しばしば骨折などの偶発症をきたし,また,治療後の健忘などの副作用が避けられない。さらに肺結核症,高血圧症,心疾患などの合併により,電撃療法をおこなうのに躊躇する場合がすくなくない。いずれにぜよ,電撃療法は患者にとつても,医師にとつても快よい治療とはいえない。持続睡眠療法は看護に手数がかかり,また,治療中肺炎などの危険な合併症を招くことがあり,次第にこの治療をおこなうことが少くなつてきている。
近年,ChlorpromazineなどPhenothiazine誘導体の各種の薬物,Serpasilなどが精神科領域の薬物療法として導入され,精神疾患の治療に画期的な進歩をもたらしたが,これらの薬物は精神運動興奮の抑制には著明な効果をみるが,精神運動制止の状態に対しては,鎮静効果以上の作用を期待することができなかつた。
Data are presented illustrating the effects of monoamine oxydase inhibitor (trade na-me: Catron) to 23 depressive patients, of whom 15 were of depression, 3 in the depres-sive state of manic-depressive psychosis, 3 of presenile depression, I arteriosclerotic de, pressive psychosis, and I depressive neuro-sis.
The prescription dosage varied from 6 to 12 mg per day, with exception of 2 cases to which the dosage of 24 mg were administe-red 2 times per day.
The results are shown as follows: (a) that proved to be remarkably effective in 6 cases, which were composed of 4 depressive patien-ts, 4 depressive state of manic-depressive psycosis, and 1 depressive neurosis. Of 5 depressive psychosis, 3 were improved and 2 slightly improved; 9 cases showed no effec-ts, of which 2 were of presenile depression and others were in the state of manic-dep-ressive psychosis; to 2 cases of presenile and cyclothymic depression, Catron would give rather bad effects; one patient failed to continue the treatment because of side-effects, (b) that, from the above stated, it can be said that Catron would be effective in the treatment of certain depressive patients.
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