健常男性における内臓脂肪とQTc時間の関連

Correlation between Visceral Fat and QTc Interval in Healthy Men

　人間ドックを受けた健常男性119例（平均年齢50±9歳，平均BMI23.2±2.7kg／m²）を対象に内臓脂肪とQTc時間の関連を検討した．QTc時間と臍レベルの腹部CTより求めた内臓脂肪面積，皮下脂肪面積およびその比，早朝空腹時のBMI，血圧，脂質，血糖との相関係数を求めた結果，QTc時間はBMIと有意な相関（r＝0.239,p＜0.01）を示し，脂肪分布については特に内臓脂肪と有意な相関（r＝0.242,p＜0.01）を示した．また，内臓脂肪面積が110cm²以上の群ではそれ未満の群に比し，QTc時間が有意に延長し（397±21：389±18msec,p＜0.05），肥満，高血圧，高コレステロール血症，糖尿病を有する頻度が高かった．非肥満を含む健常男性においてQTc時間の延長は内臓脂肪の増加と有意に相関し，インスリン抵抗性の関与が推定された．

To clarify the correlation between visceral fat andQTc interval, we determined QTc interval, visceral fatarea (V), subcutaneous fat area (S) and V/S ratio byabdominal CT, and fasting BMI, blood pressure, serumlipid and plasma glucose in 119 healthy men. QTc inter-val was significantly correlated with BMI (r=0.239, p＜0.01) and visceral fat area (r=0.242, p＜0.01). QTcinterval significantly prolonged in visceral fat group [O;V≧110cm²] as compared with in non-visceral fat group[N; V＜110cm²] (397±21: 389±18msec, p＜0.05). Obe-sity, hypertension, hypercholesterolemia and diabetesmellitus were more frequently seen in group O than ingroup N. It is suggested that prolongation of QTc inter-val was significantly associated with increased deposi-tion of visceral fat relative to insulin resistance.