Effects of Intravenous Injection of Ioversol, a Nonionic Contrast Medium, on Circulating Blood Volume:Comparison among different combinations of its dose and volume injected Ichiro Sakuma 1 , Kenji Sakuma 1 , Mitsuhiro Fukao 1 , Yasuhiro Akaishi 1 , Hiroshi Asajima 1 , Masatoshi Sato 1 , Hiroshi Shudo 1 , Kazunori Numazawa 1 , Shigeo Kakinoki 1 , Akira Kitabatake 1 1Department of Cardiovascular Medicine, Hokkaido University School of Medicine Keyword: 造影剤 , 循環血液量 , 膠質浸透圧 , contrast media , circulating blood volume , colloid oncotic pressure pp.1191-1195
Published Date 1993/12/15
DOI https://doi.org/10.11477/mf.1404900783
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Effects on circulating blood volume (CBV) of the intravenous injection of a nonionic contrast medium, ioversol, with various doses were assessed in order to find a way of injection with less effects on systemic circulation. Ioversol was injected as a bolus to 20 mongrel dogs at doses of A: 3.75 ml/kg (n=8) or B: 2 ml/kg (n=6) of a solution containing 320 mg iodine per ml, or C: 2 ml/kg (n=6) of a 240 mgI/ml solution. Colloid oncotic pressure (COP) of the bloods drawn before and 1, 2, 3, 5 min after the injection of ioversol was measured by a needle type osmometer, and changes in CBV were calculated using the COP values.

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