Contrast medium-induced expansion of circulating blood volume:Comparison between nonionic and ionic contrast media Mitsuhiro Fukao 1 , Ichiro Sakuma 1 , Yasuhiro Akaishi 1 , Kenji Sakuma 1 , Shigeo Kakinoki 1 , Takeshi Kobayashi 1 , Hisakazu Yasuda 1 1Department of Cardiovascular Medicine, Hokkaido University Keyword: 循環血液量(circulating blood volume) , 造影剤(contrast media) , 膠質浸透圧(colloid oncoticpressure) pp.1139-1143
Published Date 1990/11/15
DOI https://doi.org/10.11477/mf.1404910049
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We assessed whether the osmotic expansion of circulating blood volume (CBV) induced by nonionic contrast medium (NCM) is less than that induced byionic contrast medium (ICM). Iohexol (Io) (NCM: 795mOsm,kg H2O), 1.28g iodine/kg, was injected in-travenously into 5 mongrel dogs and blood samples were drawn at certain times. One week later, me-glumine iothalamate (Ml) (ICM:1470mOsm/kgH2O), 1.28g iodine/kg, was injected into the same dogs. Another 5 dogs received MI first and Io one week later. Colloid oncotic pressure (COP) of the blood samples was measured by a needle osmometer, and changes in CBV were calculated from the COP val-ues. The injection of to or MI resulted in an im-mediate decrease in COP, and an increase in CBV at 1 min. MI induced significantly more severe and longlasting changes in COP and CBV than Io. Nei-ther MI nor Io modified COP when they were added to the control blood samples. Thus, although NCM considerably expanded CBV, the magnitude of ex-pansion induced by NCM was less than that induced by ICM. This may explain one of the reasons why NCM causes fewer adverse reactions than ICM.

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