Effects of acetazolamide on pulmonary functions and ventilatory responses to hypercapnia and hypoxia in healthy male subjects Hirokazu Tojima 1 , Fumio Kunitomo 1 , Shinya Okita 1 , Yasutoshi Yuguchi 1 , Koichiro Tatsumi 1 , Hiroshi Kimura 1 , Takayuki Kuriyama 1 , Shohei Watanabe 1 , Yoshiyuki Honda 2 1Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University 2The Second Department of Physiology, School of Medicine, Chiba University pp.69-74
Published Date 1986/1/15
DOI https://doi.org/10.11477/mf.1404204806
  • Abstract
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 We studied the effect of acetazolamide, a potent inhibitor of carbonic anhydrase, on pulmonary functions, blood gas analysis and ventilatory responses to hypoxia and hypercapnia in healthy male subjects. The followings are the data obtained at 4 days after acetazolamide administration (500 mg/day), and compared with those before administration.

 (1) There is no significant difference in VC, FRC, FEV1.0% and DLCO. PaCO2, pH and〔HCO3-〕 decreased and PaO2, increased.

 (2) On the average, arterial PaCO2 is expected to change by 1.51 Torr for a 1-meq/l chronic change in〔HCO3-〕.

 (3) V1 and VT at rest increased while f, T1/TTOT, VCO2 and VO2, at rest did not change. VT/T1 showed increasing tendency without statistical significance.

 (4) Normocapnic hypoxic ventilatory response (HVR) increased significantly, but there was no significant change in hypocapnic HVR.

 (5) Hypercapnic ventilatory response (HCVR) increased significantly in both unloaded and loaded conditions.

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