実験的大動脈狭窄，頻拍におけるCoenzyme Q10の投与効果

Effect of coenzyme Q10 administration in experimental aortic stenosis, tachycardia

　Coenzyme Q₁₀（CoQ₁₀）は細胞内ミトコンドリアにおいて，コハク酸脱水素酵素，NADH脱水素酵素，チトクローム類と電子伝達系に関与して細胞呼吸を賦活させるといわれている^1）。そこで，心筋の酸素需要を増加させるような状態すなわち左室圧の上昇あるいは頻拍という条件下でCoQ₁₀がどのように作用するかを検討するために，雑種成犬を用い実験的に大動脈狭窄を作成，また心房ペーシングによる頻拍発作を誘発し，これらの条件下においてCoQ₁₀を投与して心筋の酸素摂取率，乳酸摂取率を測定し，心筋代謝面について検討した。

For the purpose of studying how CoQ₁₀ exerts effect in case of the oxygen demand being increased, we opened the chests of mongrel dogs after anes-thesia, made a simultaneous recording of P_LV, P_AO, P_LVEDCBF, ABF and ECG, created aortic stenosis experimentally, had tachycardia induced by atrial pacing and studied the oxygen extraction and lac-tate uptake at the time.

In aortic stenosis, it was suggested that the aero-bic metabolism would be under way with the P_LV-P_AO pressure gradient of about 30 mmHg.

In tachycardia 1.5 times the basic heart beat, meanwhile, a distinct fall in the lactate uptake was seen in 2 out of 7 cases, and this fall was improved after administration of CoQ₁₀.

Thus it was suggested that CoQ₁₀ would sup-press the anaerobic production of energy and im-prove the energy metabolism.