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BRAIN SEROTONIN METABOLISM IN EXPERIMENTAL CEREBRAL ISCHEMIA AND THE EFFECT OF COENZYME Q ADMINISTRATION Masaharu Ito 1 , Hiroyuki Matsumoto 1 , Susumu Kikuchi 2 1First Department of Internal Medicine, Sapporo Medical College 2Otaru National Sanatorium Hospital pp.155-160
Published Date 1983/2/1
DOI https://doi.org/10.11477/mf.1406205072
  • Abstract
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Bilateral ligation of common carotid arteries of male Wistar rats was produced during fasting for the periods of 15, 30 and 60 min. Thereafter the animals were killed by decapitation, and the brain was divided into the forebrain (ischemic portion), and the brain stem and the cerebellum (blood flow maintained portions by the vertebrobasilar ar-tery system). The above three portions were sub-jected to fluorophotometry of serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) accord-ing to the method described by Curzon.

In the different series of the studies, rats pre-treated with coenzyme Q (CoQ) were exposed to bilateral ligation of common carotid arteries for 60 min, and the CoQ effect upon the serotonin metabolism was investigated.

The results obtained were as follows ;

1. The 5-HT levels in the forebrain progres-sively reduced starting at 15 min (p<0. 01), and reached to 80.2% of the control value at 60 min (p<0. 001), while those of the brain stem and the cerebellum showed no significant changes.

2. The time-course changes of 5-HIAA levels up to 60 min were not remarkable in the fore-brain and the cerebellum, while those of brain stem revealed a decreasing tendency.

3. CoQ pretreatment to sham-operated rats dis-closed a gross increasing trend of 5-HT and 5- HIAA concentrations in the brain stem.

4. CoQ preadministrated brains, of which bi-lateral common carotid arteries were ligated for 60 min, showed a statistically significant elevation of the 5-HT in the brain stem (p<0. 01) and in the cerebellum (p<0. 05), while the 5--HIAA level of CoQ preadministrated brains was higher only in the brain stem as compared to that of sham-operated rats (p<0. 05),

5. The above results would lead to the hypo-thesis that CoQ treatment could activate brain serotonin metabolism in case of cerebral infarct.


Copyright © 1983, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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