小児期に大動脈弁閉鎖不全を来す疾患についての臨床的検討

Studies on the heart diseases resulting in aortic regurgitation in infants and children

　小児期に大動脈弁閉鎖不全（aortic regurgitation；AR）を来す疾患は，I型VSDに合併するARを除けば，従来稀である^1）とされていた。筆者らは最近川崎病^2）も含め種々の原因によるARを比較的多く扱う機会を得た。そこで過去5年間に筆者らが扱った心疾患児のうちでARを認めたものについて検討し，若干の考察を加えたので報告する。

Various causes resulting in aortic regurgitation, except for aortic regurgitation with ventricular septal defect, were studied and 2.5% of 500 patients, cardiac catheterization performed during last five years, revealed aortic regurgitation.

Aortic regurgitation found in association with malformations of the aortic pathway was common.

Kawasaki disease is an acute febrile illness with multisystem involvement and extensive cardiac involvement may cause sudden death due to myocardial infarction from occlusive coronary artery disease, rupture of a coronary aneurysm or conduction abnormalities. Mitral regurgitation following Kawasaki disease is now well established as coronary arterial disease, but aortic regurgitation not yet. Recently an increase number of cases of aortic regurgitation in association with Kawasaki disease have been reported. From this point of view, importance of Kawasaki disease as a new entity of acquired heart disease was discussed.