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Clinical use of Dobutamine in patients following open heart surgery Fumiki Mori 1 , Shoichi Furukawa 1 , Yasuhiro Fujii 1 , Hitoshi Mohri 1 11st Department of Surgery, Yamaguchi University School of Medicine pp.1073-1077
Published Date 1981/10/15
DOI https://doi.org/10.11477/mf.1404203860
  • Abstract
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Ten patients following open heart surgery were studied to determine the cardiovascular properties of the new inotropic agent, dobutamine. Dobutamine was infused at a rate of 5~10 μg/kg/ min during early postoperative period.

Cardiac output increased from an average of of 3.4 to 4.4 liters/min. (p<O.001) with no sig-nificant changes in heart rate. Mean arterial pressure increased from an average of 67.6 to 77.3 torr (p<O.01) with no significant changes in mean pulmonary arterial pressure. On the contrary, pulmonary wedge pressure decreased from an average of 16.1 to 13.2 torr (p<0.05). Stroke volume and stroke work index also in-creased significantly. Systemic and pulmonary vascular resistance remained unchanged.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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