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Aortocoronary bypass surgery in an 18 year-old woman with severe hypercholesterolemia (Familiar hyperlipoproteinemia IIa, Homozygote) Soichiro Kitamura 1 , Tohru Mori 1 , Susumu Nakano 1 , Katsuhiko Miyamoto 1 , Kanji Kawachi 1 , Tetsuo Sakakibara 1 , Takahisa Hotta 1 , Akira Yamamoto 2 , Yasunaru Kawashima 1 1The First Department of Surgery, Osaka University Hospital 2The Second Department of Internal Medicine, Osaka University Hospital pp.1183-1189
Published Date 1980/10/15
DOI https://doi.org/10.11477/mf.1404203658
  • Abstract
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An 18 year-old woman with severe hyper-cholesterolemia (1000 mg/dl) due to type IIa familiar hyperlipoproteinemia underwent double aortocoronary bypass surgery for unstable angina pectoris. Four months after the surgery, one of the saphenous vein grafts (LAD) became severely narrowed with resultant recurrence of angina which progressed rapidly. Re-grafting using the new saphenous vein was carried out with complete disappearance of angina again. Ten months after the second operation, both grafts to the LAD and RCA are patent and the patient is completely free from angina with no medications. The graft to the RCA has been well patent since the first surgery. The cause of the LAD graft stenosis was severe intimal-medial hyperplasia. No cholesterol deposit or foam cells were identified.

To our knowledge, no report has been made of surgical treatment for coronary artery disease due to severe hypercholesterolemia of homozygote type of hyperlipoproteinemia. Although there is no evidence that the surgery can improve the poor prognosis of this disease, it is apparent from our experience that the surgery can give an excellent amerioration of intractable angina pectoris. The effect of surgery is also evidenced by exercise EKG test and left ventricular function study during exercise.


Copyright © 1980, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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