Coronary Artery Disease in the Japanese under Age of 50:Estimation of the Mode of Progression Makoto Akaishi 1 , Yoshiro Nakamura 1 , Hiroe Nakazawa 1 , Shunnosuke Handa 1 , Masao Chino 2 , Yasuhiro Sohma 3 1Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University 2Department of Internal Medicine Ashikaga Red Cross Hospital 3Department of Cardiology Ashikaga Red Cross Hospital pp.897-902
Published Date 1980/8/15
DOI https://doi.org/10.11477/mf.1404203617
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The progression of coronary artery disease (CAD) up to the onset of the symptoms has not been documented. A review of the anatomical changes in coronary arteries of relatively young patients with CAD would supply some ideas to construct a concept of the progression of CAD. From this point of view, we analysed the coronary arteriograms of 50 patients with symptomatic CAD under age of 50 (20 to 49, mean 43. 2) whose coronary systems had at least50% narrowing in one or more major branches.

The incidence of one, two and three vessel disease and left main coronary artery disease was 48, 22, 28 and 2% respectively. 50 to 60% of significantly affected vessels showed severe narrowing more than 90% in diameter. As others reported, involvement of left anterior descending branch (LAD) was the most frequent, however, the incidence of total occlusion to the significantly obstructed vessels was low in LAD (9%) and right coronary artery (RCA, 10%), while high in left circumflex branch (LCX, 30%). Development of collateral vessels was observed only in 13 patients whose coronary obstructions were relatively severe and multiple.

Copyright © 1980, Igaku-Shoin Ltd. All rights reserved.


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