体外循環時の血中ADHの変化—循環血液量，血漿滲透圧，左房圧との関係

The changes of blood ADH levels during extracorporeal circulation:The correlation with circulating blood volume, plasma osmotic pressure and left atrial pressure

　外科的浸潤特に体外循環が生体のホルモン系に及ぼす影響についてはまだ未解決の問題が多く残されている。特にADHはその水代謝に及ぼす影響が大であり，手術による変化を知る事は重要と考えられるが測定法の繁雑さと不安定さが障害となりいまだ明確な結論を得ていない。

　今回我々は血中ADHを近年開発されたRadio—immunoassay法^1）を用いて体外循環による開心術症例の術前，術中，術後に測定し，同時に測定した血漿滲透圧，循環血液量，血漿レニン活性，左房圧などとの関係につき検討したのでその成績について報告する。

The changes of blood antidiuretic hormone (ADH) levels during extracorporeal circulation were examined by highly sensitive radioimmuno-assay and studied the correlation with circulating blood volume, plasma osmotic pressure and left atrial pressure. The preoperative ADH level was 3.0±3.6 pg/ml.

During extracorporeal circulation, ADH level elevated up to 25.3±14.5 pg/ml and returned to the preoperative level 12 hrs after operation. The level of circulating blood volume immediately after operation was essentially same as that of the preoperative period. Plasma osmotic pressure was markedly elevated during extracorporeal circulation and gradually declined to the pre-operative level during 24 hrs after operation.