Detection of reversible asynergy:Evaluation of variable interventions Shigetaka Noma 1 , Hajime Yamazaki 1 , Makoto Akaishi 1 , Shunnosuke Handa 1 , Yoshiro Nakamura 1 , Masato Tani 1 , Yukio Tashiro 2 1Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University 2Cardiopulmonary Division, Department of Pathology, School of Medicine, Keio University pp.805-809
Published Date 1985/6/15
DOI https://doi.org/10.11477/mf.1404204695
  • Abstract
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Postextrasystolic potentiation (PESP) is widely used to detect reversible asynergy of ischemicmyocardium. In this study, the qualitative and quantitative values of PESP by atrial premature beat (A-PESP) and of nitroglycerin (TNG) were evaluated in comparison with PESP by ventricular premature beat (V-PESP). In 13 close-chested dogs, preinstrumented with ultrasonic dimension gauges, the change of regional function in response to A-PESP, V-PESP and administration of TNG was studied in a total of 38 segments (infarcted 11, surrounded 18, normal 9 segments) at two weeks after coronary occlusion. In A-PESP, when atrial premature beat was introduced in appropriate range from preceding QRS wave, improvement of regional function was quantitatively as large as in V-PESP. Regional function was more improved in V-PESP than in TNG quantitatively (p<0.01), however qualitatively TNG was equal to V-PESP. Qualitatively there was no evidence that TNG+PESP was superior to either V-PESP or TNG. Morphologically, the segment in which PESP was observed showed ischemic changes in 35% of trans-mural myocardium maximally.

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