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The almost classic experimental approach to the problem, the coronary artery occlu-sion in dog and other animals has been used as an experimental model for myo-cardial infarction in man. Experiments in animals with normal coronary arteries may not necessarily explain the sequelae of the acute event in man, in whom coronary occlusion and infarction are usually the culmination of a long-standing process of atheromatosis and sclerosis.
Nevertheless they show basic physiologic and pathophysiologic pattern, which are by reproduction in animals of great help and value to elucidate the event of coronary artery occlusion in man. In the interpreta-tion of the data, derived from animal ex-periments, it is every time the better choice to be very cautious and careful in compar-ing these results and conclusions with the clinical data. The incidence and kind of manifestations following experimental coro-nary artery occlusion varies greatly in stu-dies by different investigators, by different methods, by different animals, and even in different series of experiments by the same investigator.
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