雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

A Study on Shock:Ⅳ. Effect of Drugs on the Survival Time of Drugs that Were Clamped the Celiac and Superior Mesenteric Arteries Shigeru Matsuoka 1 , Tokio Onodera 1 , Hisashi Kushima 1 , Tomio Matsuoka 1 , Hideo Miura 1 , Morio Kasai 1 12nd Department of Surgery, Tohoku Uuiversity, School of Medicine pp.813-816
Published Date 1969/9/15
DOI https://doi.org/10.11477/mf.1404202071
  • Abstract
  • Look Inside

In our previous report, it was obviously demonstrated that a large amount of vaso-constrictive substances which seemed to be catecholamine or catecholamine related sys-temic blood of animals with aortic occlusion, although further analysis of the vasodilating factor of portal blood was not performed. Therefore, the present study was designed to evaluate the effect of phenoxybenzamine (α-blockade) to the survival time of the dogs with occlusion of the celiac and superior mesenteric arteries. Two other drugs, tra-sylol and hydrocortisone were evaluated in the same manner.

The drugs were injected intravenously about 10 minutes prior to arterial clamping. Dose of the drugs were mg/kg of phenoxy-benzamine, 20,000 unit/kg of trasylol, 50mg/kg of hydrocortisone respectively. No addi-tional treatments were performed to the ex-perimental animals until death.

The blood samples for measurement of lactate, pyruvate and gas analysis were serially removed. the mean survival time was as follows.

Control: 6.75 hours, phenoxybenzamine tr-eated: 21 hours, trasylol treated: 14 hours, and hydrocortisone treated: 11 hours.

The animals treated with phenoxybenza-mine or trasylol demonstrated the significant prologation of survival time. The effect of hydrocortisone was not significant. The development of metabolic acidosis and accu-mulation of lactate were closely related to the survival time and they were considerably prevented by phenoxybenzamine or trasylol.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

関連文献

もっと見る

文献を共有