Takotsubo Cardiomyopathy Induced by Administration of Aminophylline:A case report Ayumu Yamasaki 1 , Ryo Nakamura 2 , Yusuke Yamamoto 2 , Masanori Okabe 2 1Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo 2Department of Cardiovascular Medicine, Saiseikai-Fukuoka General Hospital Keyword: たこつぼ型心筋症 , アミノフィリン , カテコラミン , takotsubo cardiomyopathy , aminophylline , catecholamine pp.529-533
Published Date 2011/5/15
DOI https://doi.org/10.11477/mf.1404101705
  • Abstract
  • Look Inside
  • Reference

 A 76-year-old man was admitted to another hospital for rehabilitation after old cerebral infarction. Because of a fever and mild dyspnea at rest, he was diagnosed as having acute bronchitis. Intravenous aminophylline(500mg)was given initially. Then administration of intravenous aminophylline(250mg/day)and antibiotics was started every day. After 4 days, he suffered from severe dyspnea and was referred to our hospital. An electrocardiogram showed marked ST elevation in the precordial leads. There was no obstruction and no significant stenosis in the emergent coronary angiography. The initial echocardiography showed left ventricular wall motion abnormality with akinesis around the apical area and hyperkinesis at the basal portion. The diagnosis was takotsubo cardiomyopathy. Tallium-201(201Tl)and iodine-123-beta-methyl-p-iodophenyl penta-decanoic acid(123I-BMIPP)dual-isotope myocardial single-photon emission computed tomography(SPECT)showed myocardial perfusion and metabolism mismatch in the apical area. The wall motion abnormality completely recovered within the following two weeks. Thus, administration of aminophylline is thought to have led to transient left ventricular dysfunction, by means of adrenergic hyperstimulation of the heart with the potential for catecholamine cardiotoxicity.

Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院