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Backgrounds of Gastric Neuroendocrine Tumors(NETs) except the Rindi Classification Masato Watanabe 1 , Toshiaki Hirasawa 1 , Kaoru Nakano 2 , Chika Fukuyama 1 , Hiroyuki Yamamoto 1 , Ken Namikawa 1 , Yoshitaka Tokai 1 , Shoichi Yoshimizu 1 , Yusuke Horiuchi 1 , Akiyoshi Ishiyama 1 , Toshiyuki Yoshio 1 1Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo 2Department of Pathology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo Keyword: 神経内分泌腫瘍 , 高ガストリン血症 , 壁細胞機能不全症 , PPI , P-CAB pp.731-736
Published Date 2024/5/25
DOI https://doi.org/10.11477/mf.1403203627
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 Gastric NETs(neuroendocrine tumors)have been classified into Type I-III according to disease background since the report by Rindi et al. in 1993. However, it has been reported that some patients with gastric NET manifest characteristics that can't be classified into either of these categories. Parietal cell dysfunction or long-term PPIs(proton pump inhibitors)or P-CAB(potassium-competitive acid blocker)administration caused these cases. Both NET cases were caused by hypergastrinemia due to hypo-/achlorhydria or prolonged acid secretion suppression. Accurately diagnosing the disease is crucial for parietal cell dysfunction, and evaluating the necessity of drug continuation is necessary for long-term PPI/P-CAB administration. Regular follow up, including endoscopy, is recommended in both cases.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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