Characteristics of Pathological Findings in Long-segment Barrett's Esophagus-Derived Esophageal Adenocarcinoma Hiroshi Kawachi 1,2 , Kaoru Nakano 1,2 , Junko Fujisaki 3 1Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 2Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 3Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo Keyword: Barrett食道 , LSBE , 腺癌 , 病理 , 多発 pp.146-153
Published Date 2021/2/25
DOI https://doi.org/10.11477/mf.1403202243
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 This review demonstrates the pathological characteristics of adenocarcinoma in the long-segment Barrett's esophagus(LSBE adenocarcinoma). Macroscopically, LSBE adenocarcinoma typically shows superficially elevated morphology, such as 0-I or 0-IIa lesions, which are occasionally accompanied by a 0-IIb component. Histologically, well-to-moderately-differentiated adenocarcinomas are commonly detected, but poorly differentiated components may be seen in deeper, more invasive regions. The 0-IIb component of LSBE adenocarcinoma comprises well-differentiated tubular adenocarcinoma with low glandular density and low-grade cellular atypia. Intestinal metaplasia is frequently observed in the background mucosa of LSBE adenocarcinoma. Multiple synchronous and metachronous lesions, including microscopic minute cancer foci, are common in LSBE adenocarcinoma. p53 immunohistochemistry is useful for the histological detection of such minute lesions.

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