Characteristics of Pathological Findings in Short-segment Barrett's Esophagus-Derived Esophageal Adenocarcinoma Kenichi Mukaisho 1 , Takahisa Nakayama 1 , Ryoji Kushima 1 1Department of Clinical Laboratory Medicine and Diagnostic Pathology, Shiga University of Medical Science, Otsu, Japan Keyword: cardiac mucosa , 噴門腺 , SSBE , GERD , adenocarcinoma pp.139-144
Published Date 2021/2/25
DOI https://doi.org/10.11477/mf.1403202242
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 Most of the SSBE(short-segment Barrett's esophagus), which is often found among Japanese patients, is primarily composed of cardiac-type mucosa. The cardiac mucosa surface consists of MUC5AC-positive gastric foveolar epithelium, and the more profound part consists of MUC6-positive cardiac glands. The area where cardiac glands are present is extremely narrow during the embryonic period and is believed to spread. The cardiac mucosa spreads to the anal side in patients with Helicobacter pylori infection, and it also spreads to the oral side in patients with gastroesophageal reflux disease. Atypical glands exhibiting the same cell distribution as that of cardiac glands(MUC5AC-positive cells on the luminal side and MUC6-positive cells deep)can be detected in the part of Barrett's EAC(esophageal adenocarcinoma)derived from SSBE. This finding suggests that SSBE-derived Barrett's EAC is originated from cardiac mucosa. The lesion is often located at the right anterior wall(0-3 o'clock position)in the lower esophagus. It has been reported that the main macroscopic type is elevated. Although SSBE has the potential to develop EAC like LSBE, it has a lower risk for carcinogenesis than LSBE. SSBE is highly unlikely to develop simultaneous multiple cancers or extraordinary multiple cancers.

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