雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Gastric Adenocarcinoma of Fundic Gland Transforming into Moderately-differentiated Tubular Adenocarcinoma with Subserosa Invasion, Report of a Case Wataru Iwai 1 , Katsuaki Kato 2 , Tomoyuki Oikawa 1 , Takefumi Miyazaki 1 , Tetsuya Noguchi 1 , Takahiro Sugai 1 , Yuta Wakui 1 , Makoto Abue 1 , Kiyoshi Uchimi 1 , Shinichi Suzuki 1 , Takashi Chiba 2 , Daisuke Shibuya 2 , Takayuki Masuda 2 1Department of Gastroenterologocal Medicine, Miyagi Cancer Center, Naotori, Japan 2Cancer Detection Center, Miyagi Cancer Society, Sendai, Japan Keyword: 胃底腺型胃癌 , 胃底腺粘膜型胃癌 , Helicobacter pylori未感染胃癌 , 進行胃癌 pp.1077-1084
Published Date 2020/7/25
DOI https://doi.org/10.11477/mf.1403202098
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 A 67-year-old man was required to undergo close endoscopic examination in keeping with population-based screening for gastric cancer. Endoscopic findings revealed a reddish, depressed lesion accompanied by submucosal tumor-like elevation at the lesser curvature of the middle gastric body. Biopsy of the lesion revealed well-differentiated tubular adenocarcinoma. Serum anti-H. pylori antibody titer was below 3U/ml, indicating that the lesion occurred in an H. pylori-naïve stomach. The lesion was considered a 0-II type gastric cancer with deeper invasion beyond the submucosal layer, therefore a total gastrectomy was carried out. Pathological findings of the surgical specimen revealed the presence of a moderately-differentiated tubular adenocarcinoma invading into the subserosa at the center of the depressed lesion. In addition, a gastric adenocarcinoma of fundic gland(chief cell predominant)(GA-FG-CCP)covered by a non-neoplastic surface epithelium was found in the deep proper layer of the gastric mucosa surrounding the 0-IIc lesion. Contiguous with GA-FG-CCP, atypical glands mimicking the surface epithelium appeared in GA-FG. Their histological features came to resemble GA-FMG. The atypical features of these neoplastic glands gradually strengthened and then continuously shifted toward moderately-differentiated tubular adenocarcinoma. Finally, the lesion was considered as an advanced adenocarcinoma derived from GA-FG, accompanied by various intermediate features.


Copyright © 2020, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有