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Histopathological Characteristics of Gastric Adenocarcinoma of Fundic Gland Type Hiroshi Tanabe 1 , Akinori Iwashita 1 , Keisuke Ikeda 1 , Atsuko Ota 1 , Kenshi Yao 2 1Department of Pathology, Fukuoka University Chikushi Hospital, Chikushino, Japan 2Department of Endoscopy, Fukuoka University Chikushi Hospital, Chikushino, Japan Keyword: 胃底腺型胃癌 , 胃底腺粘膜型胃癌 , 低異型度分化型胃癌 , 主細胞優位型 , 副細胞優位型 pp.1469-1479
Published Date 2015/11/25
DOI https://doi.org/10.11477/mf.1403200463
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 Twenty-one lesions in 18 patients showing differentiation of the tumor cells of the fundic gland observed at the Department of Pathology of the Fukuoka University Chikushi Hospital were studied to evaluate the histopathological, immunohistological, and clinicopathological characteristics of these cells. We found that the gastric adenocarcinomas that differentiate into carcinoma of the fundic gland can be broadly categorized as gastric adenocarcinoma of fundic gland type and gastric adenocarcinoma of fundic mucosa type. When defining lesions comprising tumor cells that are 1)significantly more positive for pepsinogen I, i.e., the chief cell-dominant type, 2)significantly more positive for MUC6, i.e., the mucous neck cell-dominant type, and 3)equally positive for pepsinogen I and MUC6, i.e., the chief-mucous-neck-combination type, we found that those comprising tumor cells of the chief cell-dominant type were the most common, appearing in 9/15 cases of gastric adenocarcinoma of fundic gland type. However, the mucous neck cell-dominant type(2 cases)and chief-mucous-neck- combination type(3 cases)appeared in majority in 6 cases of gastric adenocarcinoma of fundic mucosa type. In terms of average tumor diameters, the tumors of the fundic mucosa type were larger(6.5mm)than those of the fundic gland type(2.9mm). Furthermore, all lesions of the fundic mucosa type represented pT1b1(SM1). These results suggest that lesions of the chief cell-dominant type are relatively small and gradually spread from the middle to the deeper layers of the mucosa, whereas those of the chief cells, mucous neck cells, and foveolar epithelial cells that differentiate in many directions rapidly spread to form large tumors.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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