Diagnostic Criteria and Problems of Dysplasia/Cancer in Ulcerative Colitis Hiroyuki Hayashi 1 , Kyoko Ono 1 , Akira Sugita 2 , Kazutaka Koganei 2 1Department of Pathology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan 2Inflammatory Bowel Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Japan Keyword: 潰瘍性大腸炎 , colitic cancer , dysplasia , 組織診断 pp.1502-1508
Published Date 2019/10/25
DOI https://doi.org/10.11477/mf.1403201862
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 The histological diagnosis of dysplasia plays a crucial role in the management of patients with inflammatory bowel disease ; however, the diagnostic criteria are still confusing, and distinguishing sporadic adenoma from reactive epithelial change can be challenging. Increased nuclear-to-cytoplasmic ratio and diffuse nuclear hyperchromasia, uncrowded and weakly branched straight glands, and p53 abnormality are the common histological features of dysplasia. Dystrophic goblet cells and neuroendocrine differentiation are characteristic to dysplasia.

Copyright © 2019, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院