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The Clinicopathological Features of Neuroendocrine Tumor of the Appendix-Particularly Clinical and Biological Behavior of Goblet Cell Carcinoid of the Appendix Atsuko Ota 1 , Akinori Iwashita 1 , Seiji Haraoka 1 , Keisuke Ikeda 1 , Hiroshi Tanabe 1 , Kaname Oshige 1 , Kentaro Imamura 1 1Department of Pathology, Fukuoka University Chikushi Hospital, Chikushino, Japan Keyword: 虫垂内分泌細胞腫瘍 , 杯細胞カルチノイド , 免疫組織化学 , 粘液形質 , ミスマッチ修復遺伝子蛋白 pp.451-462
Published Date 2014/4/25
DOI https://doi.org/10.11477/mf.1403114115
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 GCC(Goblet cell carcinoid)of the appendix is an uncommon neoplasm, and its malignant potential remains unclear. This study aimed to elucidate the clinicopathological and immunohistochemical features of appendiceal GCC and to determine whether it should be regarded as an adenocarcinoma or a variant of classic carcinoid tumor. We reviewed 11 cases(eight men, three women; median age 53.5 years). Histologically, the tumors were composed of mature epithelial cells such as mucus-producing cells and Paneth cells. Perineural invasion was observed in all cases. The rate of lymphatic permeation and venous invasion was high(72.7%). Seven patients were treated by ileocecal resection, and all tumors showed lymph nodal metastases. Five patients continue to be alive and asymptomatic, whereas three died within 24 months from peritonitis carcinomatosa. On the basis of these results, we emphasize that appendiceal GCC has distinctive clinicopathological and immunohistochemical features portraying an aggressive behavior as well as adenocarcinomatous features.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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