Clinicopathologic Characterization of the Appendiceal Carcinomas Takuo Hayashi 1 , Kieko Hara 1 , Yimit Alkam 1,2 , Takashi Morimoto 1,3 , Takashi Murakami 1,3 , Lee Se Yong 1,3 , Yasuhiro Hidaka 1,3 , Ryosuke Gushima 1,4 , Hiroyuki Mitomi 1 , Takashi Yao 1 1Department of Human Pathology, Juntendo University School of Medicine, Tokyo 2Department of Breast and Endocrine Surgery, Juntendo University School of Medicine, Tokyo 3Division of Gastroenterology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo 4Department of Gastroenterology and Hepatology, Kumamoto University of Medicine, Kumamoto, Japan Keyword: 低異型度粘液性腫瘍 , 粘液性囊胞腺癌 , 杯細胞カルチノイド , 粘液形質 , ミスマッチ修復遺伝子 pp.1975-1982
Published Date 2012/12/25
DOI https://doi.org/10.11477/mf.1403113678
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 We reviewed 19 appendiceal carcinomas(3 low-grade appendiceal neoplasms, 1differented adenocarcinoma, 1mucinous carcinoma, 1poorly differented adenocarcinoma, 11mucinous cystadenocarcinomas and 2goblet cell carcinoids)that had been resected surgically between 1995 and 2012. An immunohistochemical panel of MUCs(mucin core peptides)and CD10 was performed. In addition, decreased expression of DNA mismatch repair protein was analyzed immunohistochemically. The results showed that 9/11(82%)mucinous cystadenocarcinomas had gastrointestinal-mixed phenotype, that is, immunopositive for MUC5AC and MUC2. In contrast, low-grade appendiceal neoplasms, adenocarcinoma, and goblet cell carcinoids were immunonegative for MUC5AC. These results indicate that appendiceal mucinous cystadenomas may be distinct tumors that have gastrointestinal phenotype frequently, and some of these cancers may develop through the serrated neoplasia pathway.

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