Stomach and Intestine(Tokyo) Volume 48, Issue 8 (July 2013)

Analysis about the Association with Hyperplastic Polyp and SSA/P in the Right Side Colon Yoshihito Tanaka 1 , Hiro-o Yamano 1 , Kenjiro Yoshikawa 1 , Ryo Takagi 1 , Eiji Harada 1 , Michiko Nakaoka 1 , Takanori Aoki 1 , Ryogo Himori 1 , Yuko Katano 1 , Makoto Nagatsuka 1 , Kentaro Sato 1 , Yasushi Imai 1 , Tamotsu Sugai 2 , Eiichiro Yamamoto 3 , Hiromu Suzuki 3 1Department of Gastroenterology, Akita Red Cross Hospital, Akita, Japan 2Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, Morioka, Japan 3Department of Molecular Biology, School of Medicine, Sapporo Medical University, Sapporo, Japan Keyword: hyperplastic polyp , 拡大内視鏡 , SSA/P , translational research pp.1184-1190
Published Date 2013/7/25
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 Originally HP(hyperplastic polyp)of large intestine was considered to be non-neoplastic polyp. But recently, association with HP and serrated adenoma is pointed out by clinic-pathology and molecular biology.

 We divided 44 HPs of right colon into three groups according to WHO classification to clarify their clinic-pathologic character, magnifying-endoscopic feature and genetic background.

 There were a lot of MVHP(microvesicular hyperplastic polyps)in appendix and ascending colon. In addition, magnifying-endoscopic feature of MVHP was type II-open or type II-long shaped pit pattern, and genetic mutation was BRAF.

 From a result of this study,it was shown that SSA/P and MVHP had similarity in location, pit pattern, and gene background.

 The possibility that MVHP grows in SSA/P was suggested. However, on the other hand, there are still many indistinct points about HP. It is desirable to continue a translational research in more large cases of HP in future.

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48巻8号 (2013年7月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院