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A Clinicopathological Analysis of Vascular Invasion in Advanced Cancer: A diagnostic criteria for the vascular invasion of gastric cancer in relation to prognosis K. Nagao 1 , O. Matsuzaki 1 , G. Ide 1 , S. Onoda 2 , K. Isono 2 , H. Sato 2 1Department of Pathology, School of Medicine, Chiba University 22 nd Department of Surgery, School of Medicine, Chiba University pp.677-685
Published Date 1975/5/25
DOI https://doi.org/10.11477/mf.1403112361
  • Abstract
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 Changes in the venous system involved in primary foci of gastric cancer have been investigated using autopsy materials. These are divided into two groups: with or without hematogenous hepatic metastases. Tumor cell emboli (type A) occur following cancerous erosion of the endothelium in the vein system. By contrast, in the group without hepatic metastases, vascular obstruction due to tumor cell invasion is seen which is either caused by compression of tumor cell in the venules (compressive obstruction; type B) or by subendothelial invasion in the medium-sized veins (pseudoemboli of tumor cells; type C).

 Seventy two surgical materials of gastric cancer are then examined based on these findings; Type A changes are frequently observed (85.7%) in cases with poor prognosis dying within 3 years, whereas type B changes are mostly seen in those cases with a long-survival rate of over 10 years and type C is seen in 73.3 percent of those cases with a relatively long-survival rate ranging from 5 to 10 years.

 From these findings, it is concluded that type A changes including cancerous erosion and tumor cell emboli should solely be diagnosed as positive findings of vascular invasion in gastric cancer, whereas both type B and C changes should not be done so.

 The significance of the present results has been emphasized from the fact that these can be closely related to other factors such as INF classification and lymph node involvements that influeuce prognosis of gastric cancer.


Copyright © 1975, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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