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Cronkhite-Canada症候群は非遺伝性に主として中年以後に発症し,消化管polyposisに皮膚色素沈着,爪の萎縮および脱毛を伴うきわめて稀な疾患とされている.
最近,われわれは短期間に胃polyposisの著明な増大を認めた本症候群の1例を経験し,剖検する機会を得たので報告する.
A report is made of an autpsied case of Cronkhite-Canada Syndrome associated with gastric polyposis enlarged markedly in about 5 months.
The patient, a 69-year-old woman, was referred to our hospital because of pitting edema of the lower legs, loss of scalp hair, nail atrophy, hyperpigmentation of the extremities and abdominal pain. X-ray and endoscopic examinations revealed diffuse polyposis in the stomach, small intestine and colon. After 5 months, she was admitted with the chief complaints of marked edema and general fatigue. Laboratory studies showed hypoproteinemia (T.P. 3.3 g/dl) and achlorhydria. The amount of fecal fat was 8.6 g per day. The half-life of 131I-RISA was shortened to 7 days. Roentgenographic and endoscopic examinations showed that gastric polyposis had enlarged markedly as compared with the previous findings 5 months before.
The patient died of general weakness 17 months after the onset of symptoms.
Multiple adenomatous polyp formation of the stomach, small and large intestines was found on autopsy.
Microscopically, marked stromal edema, dilatation of the capillaries and lymphatic channels were also noticed, especially in those of the larger gastric ones.
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