Gastric Carcinoids of Animal J. Soga 1 1Department of Surgery, Section of Pathology, University of Niigata School of Medicine 2Division of blood Transfursion University of Niigata Hospital pp.757-763
Published Date 1970/6/25
DOI https://doi.org/10.11477/mf.1403111305
  • Abstract
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 Investigation of carcinoid tumors of man has recently become an area of renewed interest in the metabolism of the serotonin and its related substances along with histamine in relation to clinical manifestations. While the gastric carcinoids in man are rare, not more than 100 cases reported up to date, the African rodent, Praomy (Mastomys) natalensis, has recently been found to produce gastric carcinoids in a high incidence (Snell). Some characteristics of these tumors from our stock Mastomys are discussed with a special emphasis on pathogensis as to their argyrophil cell origin.

 Out of 130 malignant epithelial neoplasms from the glandular stomachs of Mastomys histologically confirmed, 71 that were identical to the remaining tumors were under the present study with reference to the argyrophil reaction. Of these 71 tumors, 43 (61%) showed a definitely positive argyrophil reaction(Sevier-Munger), while most of those tested were non-argentafiin. These tumors were therefore considered to be argyrophil cell carcinoicls.

 It is well known that most of gastric carcinoids of man are of argyrophil cell origin as well. While some silmilarities between carcinoids of man and those of Mastomys were found, some differences between these two were also encountered : as many as 52% of the former (Brodman, 1968) but none of the latter originated in the pyloric antrum and along the lesser curvature; the incidence of intragastric multiplicity was 41.5% in the latter in comparison with only 6.2% in the fomnel(Brodman).

 Specific secretory granules measuring 150 mμ to 250mμ in diameter surrounded by a typical wavy limiting membrane were also evident in these Mastomys tumors on the electron micrographs.

 It is emphasized that Mastomys may well be utilized for model experiments concerning the metabolic, symptomatologic and clinicopathologic analysis of the carcinoicl patients.

Copyright © 1970, Igaku-Shoin Ltd. All rights reserved.


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