雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Histogenesis of Carcinoid Tumors J. Soga 1 1Cancer Research Section, Department of Surgery University of Niigata School of Medicine pp.625-633
Published Date 1975/5/25
DOI https://doi.org/10.11477/mf.1403112334
  • Abstract
  • Look Inside

 Some considerations on histogenesis of carcinoids are undertaken on the basis of our recent concept of the neoplasms of this particular category that carcinoids are a group of endocrine neoplasms originaing from the primordial cells of the endocrine or related cells of multiple sorts widely distributed in the organs and tissues of the primitive gut system.

 Morphologic variety reflected in the histologic classification, behavior to silver impregnations, occasionally encountered multisecretory function, atypical forms represented mainly by mixed type and by C type with concomitant mucus-secretion, coexistence of neoplastic cells of different types in a single neoplasm, and argyrophil cell microproliferations including microcarcinoids are all taken into consideration for the present discussion on histogenesis of carcinoids as the keys to possible solution of this problem.

 One of the hypotheses concerning the mechanism of neoplastic transformation of these neoplasms postulates that the neoplastic transformation may encounter with the preprimordial anlage cells in the Mphase in which these cells are capable of multidirectional differentiation and may result in multisecretory or mixed type carcinoids or in C type carcinoids with mucus-secretion including argentaffin cell adenocarcinoma (Soga) and goblet cell carcinoid of the appendix (Klein, Subbuswamy), and that it may as well act on the primordial anlage cells in the U-phase in which these cells are capable of unidirectional differentiation under the control of the field and may result in monosecretory or histologically uniform (A, B and some of C and D) type carcinoids. Thus, morphologic variety of carcinoids in histologic classification may well be considered to be a fairly faithful reflection of histogenetic variety of these neoplasms.

 It is, however, emphasized that the theoretical consideration on histogenesis of carcinoids should be more precisely established mainly on the basis of the testified phenomena supplemented by certain hypotheses only on inevitable occasions.


Copyright © 1975, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有