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Morphologioal Aspects of Gastric Mucosal Defensive Mechanism Tadayoshi Takemoto 1 1The First Department of Internal Medicine, Yamaguchi University, School of Medicine pp.1165-1172
Published Date 1986/11/25
DOI https://doi.org/10.11477/mf.1403110110
  • Abstract
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 To investigate the gastric mucosal mechanism in clinical fields, we must consider the changes in chronic gastritis such as atrophic gastritis, superficial gastritis and intestinal metaplasia. By considering background gastric mucosa of AGML from the viewpoint of pathology, we know that acute gastric erosions and ulcers are frequently formed on the gastric mucosa without changes being brought about in the chronic gastritis especially in the case of intestinal metaplasia. After administration of bile acid under fiberoptical control, in chronic gastritis, gastric mucosal blood flow did not decrease as it does in normal gastric mucosa. The level of SOD (superoxide dismutase) was high in intestinal metaplasia.

 We consider the change of AGML involves diffuse changes of the upper gastrointestinal tract. Among the diffuse changes are mucosal bleeding, erosions and ulcers which are formed locally. The progress and the degree of these localized erosions and ulcers depend on the degree of the background chronic gastritis especially intestinal metaplasia.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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