The Study of the Image Analysis of the Gastric Mucus: Including phospholipid as the mucosal barrier Syuji Asada 1 , Masahiro Shiraki 1 , Ichiro Hirata 1 , Hirofumi Miyoshi 1 , Saburo Ohshiba 1 1The Second Department of Internal Medicine, Osaka Medical College pp.1173-1181
Published Date 1986/11/25
DOI https://doi.org/10.11477/mf.1403110112
  • Abstract
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 Among various defensive factors of the gastric mucosa, the mucous gel and the hydrophobic barrier of phospholipids especially seem to play an important role in direct protection against aggressive factors. The gastric mucus is abundantly distributed throughout the gastric surface and in the surface mucosal cells. The characteristics and distribution of this mucus were easily identified using histochemical method. However, it was difficult to quantify it. We quantified the PAS positive mucus as the area ratio (%) of the mucous part and the mucosal layer, using VIP (Video Image Processor) (Fig. 1,2). This method made it possible to evaluate the mucous quantity in the gastric mucosal layer (Fig. 12 a, b).

 As a result, we found that the amount of mucus in the mucosa adjacent to ulcers increased at the healing stage and decreased at the scarring stage in patients with chronic gastric ulcers (Fig. 4, 5). Moreover, the administration of anti-inflammatory drugs caused a decrease of the amount of gastric mucus, resulting in gastric mucosal damage (Fig. 7 a, b, 8, 9).

 Our data suggest that the amount of gastric mucus is closely related to the prevention of the development of ulcers and to their healing.

Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.


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