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Ménétrier's Disease Associated with Gastric Ulcer Perforation, Report of a Case T. Kawano 1,2 , T. Watanabe 1,2 , H. Hoshino 1,2 , N. Goseki 1 , M. Menjo 1 1The First Department of Surgery, Tokyo Medical and Dental University School of Medicine 2Kita Hospital pp.1209-1214
Published Date 1983/11/25
DOI https://doi.org/10.11477/mf.1403109265
  • Abstract
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 A 32 year-old man complaining of severe upper abdominal pain was admitted to our hospital in March 1978. He was diagnosed to have Ménétrier's disease with hypoproteinemia in 1975 and gastric ulcer in 1976, and was given conservative therapy at a clinic for some time.

 Upon admission, general peritonitis due to ulcer perforation was suspected. In the emergency operation, gross finddings in the abdominal cavity revealed a perforated ulcer and a possible carcinoma both in the lesser curvature of the stomach. Total gastrectomy was performed.

 In the specimen, giant granulated mucosal folds resembling cerebral convolutions were found extensively, especially along the lesser curvature of the corpus.

 Histological findings revealed general hyperplasia of both foveolar epithelia and gastric glands of intermediate zone. Cystic dilatations of pseudopyloric glands were also present extensively in this zone which was very wide in surface area compared to that of a normal stomach. Fibrous thickening of the gastric wall from submucosal layer to serosa in the vicinity of the perforated ulcer was also noted.

 The patient had a good postoperative course with normal serum protein concentration.


Copyright © 1983, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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