Two Cases with Cronkhite-Canada's Syndrome: With special reference to histologic changes in polyposis H. Imai 1 , H. Watanabe 1 , G. Yamagishi 1 , T. Gomi 1 , S. Yamagata 1 13rd Dept. of Int. Med., Tohoku Univ. School of Med pp.783-789
Published Date 1973/6/25
DOI https://doi.org/10.11477/mf.1403108539
  • Abstract
  • Look Inside

 Two cases with Cronkhite-Canada's syndrome are described in this paper.

 Case 1: A 57-year-old woman was admitted to the hospital complaining of both atrophy and falling-off of nails, diarrhea and loss of weight. Serum proteins were 5.8 gr. per 100 ml, with Gordon's test 4.6 per cent. The amount of fecal fat was 10.4 gr. per 24 hours. Except for the esophagus, roentgenogram revealed multiple polyps all through the digestive tract. Endoscopy also demonstrated numerous hemispheric polyps in the stomach, duodenum and colon. Laparotomy was performed under a diagnosis of polyposis of the digestive tract, and the terminal ileum was excised about 10 cm long. Changes observed by histology were distinct cystic dilatation of the glands, cellular infiltration, enlarged, edematous stroma and dilatation of lymph vessels in the submucosa.

 Case 2: A man aged 57, who had undergone gastrectomy 13 years before on account of peptic ulcer, was hospitalized, complaining of severe diarrhea of four months' duration, increasing pigmentation on hands and feet, falling-out of hair and atrophy of nails. Serum proteins were 3.6 gr. per 100 ml, Gordon's test being 2.7 per cent. The amount of fecal fat was 18.1 gr. per 24 hours. x-ray examination revealed multiple, disseminated polyps in the gastric remnant, small intestine and colon. Those in the gastric stump and colon were demonstrated by endoscopy as well. Biopsy of the colon showed changes such as enlarged, edematous stroma and cellular infiltration, although cystic dilatation of glands were not so remarkable. In addition, dilated serpentine vessels were pictured by lymphography.

 Histologic picture in this case showed in typical parts meager atypicality of glandular epithelia, cystic dilatation of glands, hypersecretion of mucus, enlarged, edematous stroma and cellular infiltration, all resembling those characteristics as are seen in juvenile polyp of the colon. Abnormal observations in the lymph vessels were thought closely rerated with the mechanism with which protein is lost into the digestive tract.

Copyright © 1973, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院