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Local Application of Bleomycin in Cancer of the Stomach, a Case Report M. Namiki 1 , K. Mizushima 1 , H. Kawauchi 1 , K. Nakagawa 1 1The 3rd. Dept. of Internal Medicine, Asahikawa Medical College pp.1713-1716
Published Date 1979/12/25
DOI https://doi.org/10.11477/mf.1403107871
  • Abstract
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 A 65 year-old male underwent an upper gastrointestinal series and endoscopic examination of the stomach revealing a malignant lesion which manifested as a giant protrusion located in the greater curvature toward the posterior wall of the antepyloric region.

 Histological findings of structural and cellular atypities was documented from lesion specimens obtained during endoscopic examination. The patient refuse to undergo the recommended operative treatment. Consequently. local injection of Bleomycin into the cancer became the chosen treatment.

 Two ml of Bleomycin (3mg/ml) in sterile distilled water was injected directly into the cancer. Three days later, a second injection of the same amount of the solution as repeated. One week after the second injection, massive necrotized tissue was removed by endoscopic forceps with an additional injection of Bleomycin. Thereafter, repeated Bleomycin injection and removal Of necrotized masses were performed weekly. Consequently, no previous lesion was recognized under endoscopy after 18 procedures and biopsy specimens on the last endoscopy no longer manifested malignant histological findings.

 Thereafter he was examined endoscopically at regular intervals and no recurrence was found. Finally he died of mycocardial infarction 19 months after his discharge from the clinic.


Copyright © 1979, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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