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Endoscopic Local Injection Therapy for Gastric Cancer K. Harada 1 , K. Mizushima 1 , M. Namiki 1 1The Third Department of Internal Medicine, Asahikawa Medical College pp.895-902
Published Date 1984/8/25
DOI https://doi.org/10.11477/mf.1403109574
  • Abstract
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 Since 1965, we have been performing endoscopic local injection therapy with bleomycin in gastric cancer. We have treated 27 cases of early gastric cancer with this method. All patients were unable to undertake operations for some reasons. 2 ml of bleomycin (3 mg/ml) in sterile distilled water was injected directly into the tumor. One week after the second injection, massive necrotized tissues were removed by endoscopic forceps. Repeated bleomycin injection and removal of necrotized masses were performed weekly until the tumor could not be recognized. There was no relapse for 16 years at the longest in a patient with early gastric cancer of Ⅱa type.

 There are other endoscopic local injection therapy using mitomycin,OK-432 (picibanil), ethanol, etc. Mechanism of OK-432 suggested that macrophage appeared. With the use of mitomycin and ethanol, it was difficult to control the ulceration to tumor or normal tissue. Protruded-type of early gastric cancer is suitable for endoscopic local injection therapy. It was not effective to metastatic lymph nodes, therefore, fat emulsion of anticancer agents have been deviced. If surgical therapy is not applicable due to high risks, endoscopic local injection therapy is valuable for gastric cancer.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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