Advanced Gastric Cancer Arising in a Patient with Ménétrier's Disease, Report of a Case Toshinari Minamoto 1 , Masayoshi Mai 1 , Tohru Asai 1 , Hiroshi Ueda 2 , Yasushi Deguchi 1 , Andrzej Sory 1 1Department of Surgery, Cancer Research lnstitute, Kanazawa University 2Department of Surgery, Tatsunokuchi Houju Memorial Hospital Keyword: Ménétrier病 , 胃癌 , 胃底腺領域 pp.1059-1065
Published Date 1994/9/25
DOI https://doi.org/10.11477/mf.1403105915
  • Abstract
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 We demonstrated here advanced gastric cancer arising in a 68-year-old man with a 15 year history of Ménétrier's disease. Three months after admission, the patient died of carcinomatous peritonitis and lymphangiosis of both lungs in spite of undergoing extensive chemotherapy. An autopsy was limited to the abdominal cavity. Gross appearance of the stomach showed gyrous-shaped big folds covering most of the fundic glandular field. A firm tumor, measuring 6.5×4.0cm, was found in the area of the big folds. No primary tumor was detected in any organ such as the small intestine, large bowel, pancreas or hepatobiliary system. Histologically, most of the big folds of the stomach were composed of hyperplasia and cystic dilatation of the foveolar ducts, compatible with the Ménétrier's disease. The coexistent gastric tumor consisted of a well differentiated tubular adenocarcinoma invading the serosa and progressing to carcinomatous peritonitis. In the lamina propria, the adenocarcinoma was intimately close to the hyperplastic foveolar ducts, suggesting a transition between the both. These findings together with several case reports similar to the current study indicate that Ménétrier's disease has a potential to give rise to adenocarcinoma in the fundic gland fields of the stomach.

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