Differentiated Adenocarcinoma in Fundic Glandular RegionIts Characteristics and Histogenesis Shingo lshiguro 1 , Naoko Tsuji 1 , Toshiyuki Terao 1 , Yumiko Koyanagi 1 , Ryuhei Tateishi 1 1Department of Pathology, The Center For Adult Diseases Keyword: 胃底腺領域 , 分化型癌 , 腺窩上皮型癌 , 未分化型癌 pp.1025-1029
Published Date 1994/9/25
DOI https://doi.org/10.11477/mf.1403105908
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 To investigate the pathological characteristics of differentiated adenocarcinoma in the fundic glandular region, we reviewed 375 cases of gastric carcinoma less than 20 mm in diameter.

 Cancer foci surrounded continuously by normal fundic glands were found in 17 cases (4.5%). Among these 17 cases, 12 were undifferentiated type, 4 were mixed differentiated and undifferentiated type, and only one was differentiated type.

 Histologically, differentiated parts of the mixed type carcinomas and the differentiated type carcinomas were gastric type adenocarcinoma (foveolar type adenocarcinoma) containig GOS and Con A Ⅲ positive cancer cells. The undifferentiated parts of the mixed type carcinomas showed similar histological appearances as pure undifferentiated carcinomas.

 On the other hand, the noncancerous epithelium surrounding the cancer foci of all 17 cases showed mild pyloric glandular metaplasia. Intesinal metaplasia was never obseved.

 Other clinico-pathological appearances were also similar in all 17 cases.

 As a result, we concluded that differentiated carcinoma in the fundic glandular region is gastric type adenocarcinoma (foveolar type adenocarcinoma) originating from the gastric proper mucosa. There was a possibility of its changing into undifferentiated carcinoma.

Copyright © 1994, Igaku-Shoin Ltd. All rights reserved.


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