Histogenesis of Barrett's Adenocarcinoma: Analyses of Human Samples and Results of Experimental Animal Studies Ken-ichi Mukaisho 1 , Ryoji Kushima 2 , Shizuki Takemura 1,3 , Yoshio Araki 1 , Michael Vieth 4 , Hiroyuki Sugihara 1 , Takanori Hattori 1 1Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 2Clinical Laboratory Divison, National Cancer Center Hospital, Tokyo 3Ritto-Shizuki Pathology Clinic, Ritto, Japan 4Institut für Pathologie, Klinikum Bayreuth GmbH, Bayreuth, Germany Keyword: specialized intestinal metaplasia , cardiac-type mucosa , LSBE , SSBE , 胃・十二指腸液逆流モデル pp.1861-1874
Published Date 2011/11/25
DOI https://doi.org/10.11477/mf.1403102416
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 We discuss the histogenesis of Barrett's adenocarcinoma following the histopathological examination of esophageal adenocarcinoma specimens obtained from the lower esophagus of German individuals. We also include experimental results obtained using rat duodenal contents reflux models. We observed that cardiac-type mucosa in short-segment Barrett's esophagus develops by proliferation of the cardiac glands that exist in the gastric cardia or esophagogastric junction. On the other hand, SIM(specialized intestinal metaplasia)in long-segment Barrett's esophagus occurs through metaplastic change from stem cells located in the basal layer of squamous cell epithelium. This occurs because of esophageal exposure to gastric contents including highly concentrated bile acids. Moreover, the rate of carcinogenesis following SIM in LSBE is higher when compared to that following proliferation of cardiac-type mucosa in SSBE.

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