Japanese

Comparative Histopathological Study of H. pylori-positive and Negative Gastric Carcinomas Ryoji Kushima 1 , Akiko Matsubara 1 , Rie Kakinoki 1 , Shizuki Takemura 2 , Masamichi Bamba 3 , Mitsuaki Ishida 4 , Hidetoshi Okabe 4 , Yasuharu Saito 5 , Takanori Hattori 2 1Division of Diagnostic Pathology, Shiga University of Medical Science Hospital, Otsu, Japan 2Department of Pathology, Shiga University of Medical Science, Otsu, Japan 3Department of Pathology, Saiseikai Shiga Hospital, Otsu, Japan 4Department of Laboratory Medicine, Shiga University of Medical Science Hospital, Otsu, Japan 5Division of Endoscopy, Shiga University of Medical Science Hospital, Otsu, Japan Keyword: H. pylori , 萎縮粘膜 , 非萎縮粘膜 , 胃癌形質発現 , 組織発生 pp.967-980
Published Date 2007/5/25
DOI https://doi.org/10.11477/mf.1403101115
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 We reevaluated the characteristics and histogenesis of gastric carcinomas from comparative studies of H. pylori-positive and negative cases of gastric carcinomas. According to the Updated Sydney system, we selected ordinary gastric cancers arising in nonatrophic mucosa without H. pylori infection ; one of 87 cases(1.1 %)obtained by endoscopical submucosal resection(ESD)and 15 of 445 cases(3.4 %)obtained by surgical resection. Histopathological score(chronic inflammation, atrophy, intestinal metaplasia)of gastritis surrounding differentiated adenocarcinoma arising in atrophic mucosa with H. pylori infection is about 1.6 points, respectively ; indicating that most adenocarcinomas may develop in mild to moderately atrophic mucosa. Including these cases, we collected gastric carcinomas arising in nonatrophic mucosa without H. pylori infection ; 7 cases of the differentiated-type(41~82, mean age of 67 years)and 14 cases of the undifferentiated-type(41~82, mean age of 62.5 years). They were likely to develop in the fundic gland mucosa and show gastric-type differentiation. However, the intestinalization of gastric carcinoma cells was clearly demonstrated by expression of CDX2-protein, which suggests their being time-dependent in their development, with tumor progression being independent of the surrounding mucosa.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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