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Chronic Atrophic Gastritis as Background of Early Gastric Cancer Yasuyuki Kudo 1,2 , Shinichi Tsutsumi 1,4 , Seiichi Hara 1,3 , Harue Akasaka 1,4 , Hiroyuki Jin 1,4 , Satoko Morohashi 1 , Fuyuki Sato 1 , Norihiro Hanabata 2 , Tetsuro Yoshimura 2 , Shinsaku Fukuda 2 , Hirosi Kijima 1 1Department of Pathology and Biosience, Hirosaki University School of Medicine, Hirosaki, Japan 2Department of Gastroenterology and Hematology, Hirosaki University School of Medicine, Hirosaki, Japan 3Division of Gastroenterology and Hepatology, Depertment of Internal Medicine, Toho University Oomori Medical Center, Tokyo 4Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan Keyword: 萎縮性胃炎 , 早期胃癌 , ESD , 粘液形質 pp.1412-1422
Published Date 2009/8/25
DOI https://doi.org/10.11477/mf.1403101739
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 The present study made a histopathological evaluation of chronic atrophic gastritis as background of early gastric cancer. We evaluated mucosal height, number of glands and degree of intestinal metaplasia of the background gastric mucosa, which was resected by endoscopic submucosal resection(ESD)for early gastric cancer. Depressed gross type and moderately to poorly differentiated adenocarcinoma of gastric-phenotype cancer cases showed 508μm/score 0.7 and 552μm/score 1.0(mucosal height/intestinal metaplasia score), respectively. The results indicated that gastric-phenotype cancers had atrophic mucosa with less intestinal metaplasia. In addition to the atrophic mucosa with intestinal metaplasia(Correa's hypothesis), atrophic gastric mucosa with less intestinal metaplasia is thought to play an important role in gastric carcinogenesis, especially tumorigenesis of gastric-phenotype cancer.


Copyright © 2009, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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