Since Helicobacter pylori Infection Play's a Important Role in Carcinogenesis of Gastric Cancer, Helicobacter pylori Eradication Has the Possibility to Reduce the Incidence of Gastric Cancer Mototsugu Kato 1 , Shoko Ono 1 , Yuichi Shimizu 2 , Masahira Haneda 2 , Tomoe Kobayashi 2 , Rumiko Asaka 2 , Keiko Yamamoto 2 , Urara Nishida 2 , Aki Imai 2 , Takeshi Yoshida 2 , Masahiro Asaka 2 , Manabu Nakagawa 3 , Soichi Nakagawa 3 1Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan 2Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan 3Nakagawa Ichouka, Sapporo, Japan Keyword: H. pylori , 除菌 , 介入試験 , 胃癌予防 , 異時性多発癌 pp.1402-1411
Published Date 2009/8/25
DOI https://doi.org/10.11477/mf.1403101738
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 Since H. pylori infection plays an important role in the carcinogenesis of gastric cancer, H. pylori eradication should have the possibility to reduce incidence of gastric cancer. Although five randomized controlled studies with gastric canser incidence as endpoint were reported, analysis and meta-analysis of the five studies showed that H. pylori eradication had no significant preventive effect for gastric cancer. However, three non-randomized interventional studies for Japanese patients with gastroduodenal ulcer showed that successful eradication of H. pylori significantly reduced gastric cancer incidence. Multi-center randomized controlled study in Japan showed that eradication of H. pylori had inhibitory effects on the development of metachronous gastric carcinomas after endoscopic resection. This is the first evidence that H. pylori eradication prevents development of gastric cancer. This study suggests that H. pylori eradication decreases the growth speed of occult cancer to such an extent that its incidence is no different to that produced by residual cancer after incomplete resection. Preventive effect probably depends on the cancer volume. New strategy including H. pylori treatment is necessary to eliminate gastric cancer from Japan.

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