Gastrointestinal Manifestations of Polyarteritis Nodosa Hiroshi Matsumoto 1 , Hideki Koga 1 , Mitsuo Iida 2 1Division of Gastroenterology, Department of Medicine, Kawasaki Medical School 2Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Keyword: PN , CPN , MPA , 消化管病変 , 虚血 pp.529-534
Published Date 2003/4/24
DOI https://doi.org/10.11477/mf.1403100910
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 To elucidate clinicogastroenterological features in polyarteritis nodosa, we retrospectively reviewed and analyzed the data from the 41 cases of PN with gastrointestinal involvement (PNGI) reported during the last 10 years in Japan. The gastrointestinal lesions were found often in middle-aged male patients. Most of the patients with PNGI were suffering from gastrointestinal bleeding or perforation of the gastrointestinal tract. Although previous reports have noted the small intestine as the most common site of this bleeding or perforation in PNGI, our study indicated that the stomach and the large intestine were as frequently involved as the small intestine in PNGI. Because of underlying vasculitis, occlusion of the vessels developed, and induced ischemia of the gastrointestinal tract, resulting in erosions, edema, ulceration, and/or perforation. In the upper gastrointestinal tract, round or oval ulcers, which should be differentiated from peptic ulcers, were characteristic. In the lower gastrointestinal tract, irregularly-shaped ulcers or perforated ulcers were often seen. Deterioration of these gastrointestinal lesions during or after endoscopic examinations was also characteristic in PNGI. To make an early and accurate diagnosis of PNGI, clinicians should be familiar with its clinicogastroenterological features.

Copyright © 2003, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院