S-1＋CDDP療法が極めて良く奏効した胃癌の2例

Advanced Gastric Cancer in Which S-1 Combined with CDDP Therapy was Successful, Report of Two Cases

要旨　手術不能胃癌に対してS-1＋CDDP療法が奏効した2例を経験した．1例は19歳の女性，4型胃癌で組織型は低分化腺癌であった．S-1＋CDDP療法を開始し4コース時点で肉眼的に認識が難しいまでに腫瘍が縮小した．現在，生存中である．1例は66歳の男性，多発肝転移を有しており，組織型は小細胞癌であった．S-1＋CDDP療法を開始し6コース時点で肝転移はほぼ消失した．現在外来にて経過観察中である．S-1＋CDDP療法は現時点で最も奏効率が高いとされているが，奏効率と生存期間の延長が必ずしも一致しないため，生存期間の延長をprimary endpoinとしたJCOG9912の結果が待たれる．

　We encountered two cases in which S-1 combined with CDDP therapy (S-1＋CDDP) was successful. Case 1 : A 19-year-old woman was diagnosed with Type 4 advanced gastric cancer. She received successful S-1＋CDDP therapy and she is still living. Case 2 : A 66-year-old man diagnosed with small cell gastric carcinoma and multiple liver metastases. He was treated successfully with S-1＋CDDP therapy. Most metastatic lesions disappeared. We have succeeded in 2 cases, but we are aware that good response to this treatment does not necessarily ensure elongation of life, so we are waiting for the results of JCOG9912 to see if the life of the patients has been lengthened or not.