Endoscopic Evaluation of Helicobacter pylori Eradication Therapy Against Low-grade Gastric MALT Lymphoma Ichiro Oda 1 , Daizo Saito 1 , Hiroyuki Ono 1 , Mitsuhiro Fujishiro 1 , Takahiro Kozu 1 1Endoscopic Division, National Cancer Center Hospital Keyword: 胃MALTリンパ腫 , Helicobacter pylori除菌療法 , 内視鏡的評価 pp.1381-1388
Published Date 1999/10/25
DOI https://doi.org/10.11477/mf.1403102842
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 The histological cure of low-grade gastric MALT (mucosa-associated lymphoid tissue) lymphoma by Helicobacter pylori (H. pylori) eradication therapy has been demonstrated. However, the existence of relapsed cases within relative short periods indicates the necessity for other useful and accurate methods of evaluation of this therapy. The aim of this study was to investigate the endoscopic mucosal change after treatment as compared with “histological evaluation”.

 Out of 30 H. pylori-positive patients with low-grade gastric MALT lymphoma treated by H. pylori eradication and followed-up for more than one year, 24 cases showed histological regression (CR: 15, PR: 9, response rate = 80%). Dividing the endoscopic findings into seven groups such as white spot, redness/erosion, edema, Ⅱc-like depression, ulceration, cobblestone appearance and protrusion, protrusion indicated the tendency of no-response to treatment and the white spot was not changed despite histological improvement. On the other hand, the other findings had a tendency to regress easily after treatment and changed to discolored mucosa like atrophy, which corresponded well with histological cure. These results suggest that “endoscopic evaluation” may be useful in the treatment of low-grade gastric MALT lymphoma.

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