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Current Status of Surveillance for Crohn's Disease-related Anal Canal Cancer and Future Challenges Kenichi Takahashi 1,2 , Sho Haneda 1,2 , Manabu Shiraki 2,3 , Yutaro Masu 2,3 , Fumie Nakayama 4 , Hirofumi Watanabe 4 1Department of Colorectal Surgery, Tohoku Rosai Hospital, Sendai, Japan 2Inflammatory Bowel Disease Center, Tohoku Rosai Hospital, Sendai, Japan 3Department of Gastroenterology, Tohoku Rosai Hospita, Sendai, Japan 4Department of Pathology, Tohoku Rosai Hospital, Sendai, Japan Keyword: Crohn病 , サーベイランス , 肛門管癌 , 直腸癌 , 痔瘻 pp.935-945
Published Date 2025/7/25
DOI https://doi.org/10.11477/mf.053621800600070935
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 In Japan, anal canal carcinomas account for 44% of Crohn's disease-related gastrointestinal cancers, and because the prognosis is poor in advanced cases, its diagnosis at an early stage through surveillance is desirable. A surveillance program involving biopsy and cytology during endoscopic examination or examination under anesthesia for patients with anorectal lesions occurring at >10 years after onset of Crohn's disease was validated in a multicenter study that began in 2015 and supported in part by Health and Labor Sciences Research Grants for Research on Intractable Diseases from the Ministry of Health, Labor and Welfare of Japan. As a result, the diagnostic rate of malignant tumors reached 5%, indicating the usefulness of the program. The current situation is that diagnosis can be made at a stage when the disease is treatable, and diagnosing cancers at an early-stage is still not possible. The future challenge is to identify high-risk groups for cancer requiring short-term surveillance and to clarify the gross and endoscopic findings of early-stage cancer in order to increase the number of cases diagnosed in the early stage.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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