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Real-Time Intraoperative Fluorescence Diagnosis and Surgical Techniques for Brain and Spinal Tumors Using Indocyanine Green Jun MUTO 1 , Yutaka MINE 2 , Yuichi HIROSE 1 1Department of Neurosurgery, Fujita Health University School of Medicine 2Section of Neurosurgery, Department of Clinical Medicine, NHO Tokyo Medical Center Keyword: インドシアニングリーン , 術中リアルタイム蛍光診断 , 血管透過性・滞留性亢進 , 脳脊髄腫瘍 , indocyanine green , intraoperative real-time photodynamic diagnosis , enhanced permeability and retention , brain and spinal tumors pp.308-316
Published Date 2025/3/10
DOI https://doi.org/10.11477/mf.030126030530020308
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 This article discusses the development and clinical application of intraoperative fluorescence-guided diagnosis for brain and spinal tumors using indocyanine green (ICG). The Delayed Window ICG (DWIG) technique enhances tumor visualization during surgery, improving resection accuracy and prognosis. By exploiting ICG's selective tumor accumulation and its correlation with MRI gadolinium contrast, DWIG enables real-time identification of tumor boundaries. This technique has demonstrated utility in various tumor types and post-radiation necrosis. Future integration with artificial intelligence and augmented reality technologies may bring advanced surgical precision and support. Expanding ICG applications in brain and spinal tumor surgeries appears to improve both safety and treatment outcomes.


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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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