爪症状を伴った先天性皮膚カンジダ症

・先天性皮膚カンジダ症を経験した．

・呼吸不全があり，カンジダ肺炎を考慮しリポソームアムホテリシンB投与を行った．

・生後5週から両手にカンジダ性の爪症状が現れた．

・爪症状に対してイトラコナゾール内服を行い8週間後には軽快した．

（「症例のポイント」より）

　

A case of congenital cutaneous candidiasis involved nail changes

　

Ishibe, Junichi1）Ohba, Misao1）Shirahama, Shigeho1）Kibe, Tetsuya2）

1）Department of Dermatology, Seirei-Mikatahara General Hospital

2）Department of Pediatrics, Seirei-Mikatahara General Hospital

　

The patient was a male newborn infant. Generalized erythema, vesicles, and pustules had been observed since birth. Skin cultures yielded Candida albicans, and we made a diagnosis of congenital cutaneous candidiasis. Because the patient’s respiratory status deteriorated, we administered artificial respiratory management until postnatal day 2. Treatment consisted of systemic administration of an antibacterial agents and liposomal amphotericin B. On postnatal day 7 the rash had largely resolved. The patient’s fingernails became opaque during postnatal week 5. We treated the patient with oral itraconazole, and 8 weeks after the start of treatment, his fingernails have been replaced with normal nails.